diff --git a/Makefile b/Makefile
index 33f7fd95..906c4097 100644
--- a/Makefile
+++ b/Makefile
@@ -5,6 +5,9 @@
 
 MAKEFLAGS += --no-builtin-rules --no-print-directory
 
+# Returns the path to the command $(1) if exists. Otherwise returns an empty string.
+find-command = $(shell which $(1) 2>/dev/null)
+
 #### Defaults ####
 
 # If COMPARE is 1, check the output md5sum after building
@@ -30,8 +33,16 @@ VERBOSE ?= 0
 PRINT ?= printf
 
 # Set prefix to mips binutils binaries (mips-linux-gnu-ld => 'mips-linux-gnu-') - Change at your own risk!
-# In nearly all cases, not having 'mips-linux-gnu-*' binaries on the PATH is indicative of missing dependencies
-MIPS_BINUTILS_PREFIX ?= mips-linux-gnu-
+# Auto-detect prefix for MIPS toolchain
+ifneq      ($(call find-command,mips-linux-gnu-ld),)
+  MIPS_BINUTILS_PREFIX := mips-linux-gnu-
+else ifneq ($(call find-command,mips64-linux-gnu-ld),)
+  MIPS_BINUTILS_PREFIX := mips64-linux-gnu-
+else ifneq ($(call find-command,mips64-elf-ld),)
+  MIPS_BINUTILS_PREFIX := mips64-elf-
+else
+  $(error Unable to detect a suitable MIPS toolchain installed)
+endif
 
 VERSION ?= us
 
@@ -81,7 +92,7 @@ else ifeq ($(UNAME_S),Linux)
         CC_CHECK_COMP := arm-linux-gnueabihf-gcc
     endif
 else ifeq ($(UNAME_S),Darwin)
-    DETECTED_OS := mac
+    DETECTED_OS := macos
     MAKE := gmake
     CPPFLAGS += -xc++
 endif
@@ -123,11 +134,19 @@ AS              := $(MIPS_BINUTILS_PREFIX)as
 LD              := $(MIPS_BINUTILS_PREFIX)ld
 OBJCOPY         := $(MIPS_BINUTILS_PREFIX)objcopy
 OBJDUMP         := $(MIPS_BINUTILS_PREFIX)objdump
-CPP             := cpp
 ICONV           := iconv
 ASM_PROC        := $(PYTHON) $(TOOLS)/asm-processor/build.py
 CAT             := cat
 
+# Prefer clang as C preprocessor if installed on the system
+ifneq (,$(call find-command,clang))
+  CPP      := clang
+  CPPFLAGS := -E -P -x c -Wno-trigraphs -D_LANGUAGE_ASSEMBLY
+else
+  CPP      := cpp
+  CPPFLAGS := -P -Wno-trigraphs -D_LANGUAGE_ASSEMBLY
+endif
+
 ASM_PROC_FLAGS  := --input-enc=utf-8 --output-enc=euc-jp --convert-statics=global-with-filename
 
 SPLAT           ?= $(PYTHON) $(TOOLS)/splat/split.py
@@ -286,7 +305,7 @@ init:
 SF := ___  ___\n/ __||  _|\n\__ \|  _|\n|___/|_|\n
 uncompressed: $(ROM)
 ifneq ($(COMPARE),0)
-	@echo "$(GREEN)Calculating Rom Header Checksum... $(YELLOW)$<$(NO_COL)"	
+	@echo "$(GREEN)Calculating Rom Header Checksum... $(YELLOW)$<$(NO_COL)"
 	@$(PYTHON) $(COMPTOOL) -r $(ROM) .
 	@md5sum --status -c $(TARGET).$(VERSION).uncompressed.md5 && \
 	$(PRINT) "$(BLUE)$(TARGET).$(VERSION).uncompressed.z64$(NO_COL): $(GREEN)OK$(NO_COL)\n$(YELLOW) $(SF)" || \
diff --git a/README.md b/README.md
index c937880b..cd982062 100644
--- a/README.md
+++ b/README.md
@@ -34,7 +34,16 @@ Under Debian / Ubuntu (which we recommend using), you can install them with the
 
 ```bash
 sudo apt update
-sudo apt install make git build-essential binutils-mips-linux-gnu python3 python3-pip clang-format-14 clang-tidy 
+sudo apt install make git build-essential binutils-mips-linux-gnu python3 python3-pip clang-format-14 clang-tidy
+```
+
+### MacOS
+
+#### 1. Install build dependencies
+Install [Homebrew](https://brew.sh) and the following dependencies:
+```
+brew update
+brew install coreutils make pkg-config tehzz/n64-dev/mips64-elf-binutils
 ```
 
 #### 2. Clone the repository
diff --git a/tools/Makefile b/tools/Makefile
index 8b8ac768..9feee76a 100644
--- a/tools/Makefile
+++ b/tools/Makefile
@@ -2,11 +2,13 @@ CC   = gcc
 
 UNAME_S := $(shell uname -s)
 ifeq ($(OS),Windows_NT)
-    $(error Native Windows is currently unsupported for building this repository, use WSL instead c:)
+	$(error Native Windows is currently unsupported for building this repository, use WSL instead c:)
 else ifeq ($(UNAME_S),Linux)
 	DETECTED_OS := linux
+	MIO0_FLAGS := --gc-sections
 else ifeq ($(UNAME_S),Darwin)
-    DETECTED_OS := mac
+	DETECTED_OS := macos
+	MIO0_FLAGS :=
 endif
 
 RECOMP_DIR := ido-recomp/$(DETECTED_OS)
@@ -30,6 +32,6 @@ recomp:
 
 mio0:
 	@echo "Building mio0..."
-	$(CC) -Wall -Wextra -Wno-format-overflow -O2 -ffunction-sections -fdata-sections -DMIO0_STANDALONE -s -Wl,--gc-sections -o mio0 mio0-decompressor/libmio0.c
+	$(CC) -Wall -Wextra -Wno-format-overflow -O2 -ffunction-sections -fdata-sections -DMIO0_STANDALONE -s -Wl,${MIO0_FLAGS} -o mio0 mio0-decompressor/libmio0.c
 
 .PHONY: all clean distclean default
diff --git a/tools/requirements-python.txt b/tools/requirements-python.txt
index 9d8bda30..1f5686f7 100644
--- a/tools/requirements-python.txt
+++ b/tools/requirements-python.txt
@@ -1,4 +1,4 @@
-spimdisasm==1.17.0
+spimdisasm==1.20.0
 rabbitizer==1.7.0
 PyYAML
 pylibyaml